The Margulis Laboratory specializes in the application of nanotechnology and advanced mass spectrometry imaging to develop innovative therapies and drug delivery systems. By leveraging nanotechnology, we aim to enhance the efficacy and specificity of pharmaceuticals through improved bioavailability and bioactivity, as well as targeted delivery to specific sites within the body. We employ mass spectrometry imaging to investigate drug interactions with target tissues, gain insights into disease mechanisms, and identify potential therapeutic targets. In addition, our research focuses on the design of delivery systems for topical drugs and cosmeceuticals, using mass spectrometry imaging to visualize their permeation and distribution across different layers of the skin. Another key area of our work is brain-targeted drug delivery. We aim to deliver therapeutics to the brain by exploiting the nose-to-brain delivery route. Using mass spectrometry imaging, we assess delivery efficiency by mapping the spatial distribution of the drug within the brain and evaluating its biological effects. This includes monitoring changes in neurotransmitters, brain metabolites, phospholipids, and amino acids, which helps us optimize the delivery strategy and better understand how therapies interact with brain tissue. Our work has attracted significant interest from the pharmaceutical, cosmetics, and related industries.